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Lp(a): an acute-phase reactant?

A Noma1, A Abe, S Maeda

  • 1Department of Laboratory Medicine, Gifu University School of Medicine, Japan.

Chemistry and Physics of Lipids
|January 1, 1994
PubMed
Summary
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Plasma lipoprotein(a) [Lp(a)] levels temporarily increase after acute myocardial infarction or surgery. Higher-density Lp(a) particles with high-molecular-weight apo(a) isoforms showed greater increases, suggesting a role in tissue repair and angiogenesis.

Area of Science:

  • Biochemistry
  • Cardiology
  • Immunology

Background:

  • Lipoprotein(a) [Lp(a)] is implicated in cardiovascular disease.
  • Its role as an acute-phase reactant is not fully understood.
  • Acute-phase reactants are involved in the body's response to inflammation and injury.

Purpose of the Study:

  • To confirm transient increases in plasma Lp(a) levels as an acute-phase reactant.
  • To clarify the significance of these Lp(a) increases in patients experiencing acute myocardial infarction and surgical operations.

Main Methods:

  • Analysis of plasma Lp(a) levels in patients post-myocardial infarction and post-surgery.
  • Characterization of Lp(a) particles and apolipoprotein(a) [apo(a)] isoforms using density-gradient ultracentrifugation and SDS-PAGE.

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  • Immunohistochemical analysis to investigate Lp(a)'s role in tissue injury.

    • Main Results:

    • Plasma Lp(a) levels showed delayed peak increases compared to other acute-phase reactants like interleukin-6, C-reactive protein, and alpha-1-antitrypsin.
    • Higher-density Lp(a) particles, containing high-molecular-weight apo(a) isoforms, increased more significantly than lower-density particles.
    • Immunohistochemistry suggested Lp(a) involvement in tissue repair and angiogenesis.

    Conclusions:

    • Lp(a) functions as an acute-phase reactant with a delayed response compared to other markers.
    • The increase in specific Lp(a) isoforms suggests a role in the inflammatory and repair processes.
    • Lp(a) may be important in tissue injury repair, particularly in angiogenesis.