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Dideoxy sequencing and structural analysis of the rat insulin-like growth factor binding protein-1 gene
1Department of Medicine, University of Illinois College of Medicine, Chicago.
Biochimica Et Biophysica Acta
|May 17, 1994
Abstract:
Insulin-like growth factor binding protein-1 (IGFBP-1) is an important modulator of IGF bioavailability. To facilitate studies of IGFBP-1 regulation and function in rodent models, we cloned the rat IGFBP-1 gene and analyzed its structure by dideoxy sequencing. The rat IGFBP-1 gene is relatively small (approximately 5 kb) and contains 4 exons and 3 introns, similar to the human IGFBP-1 gene.