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Functional Calcium Imaging in Developing Cortical Networks
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Functional Calcium Imaging in Developing Cortical Networks

Published on: October 22, 2011

Spontaneous Ca2+ spikes and waves in embryonic neurons: signaling systems for differentiation

N C Spitzer1

  • 1Dept of Biology, University of California, San Diego, La Jolla 92093.

Trends in Neurosciences
|March 1, 1994
PubMed

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Feedback Regulation of Calcium Concentration01:27

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Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...