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Secondary myelodysplastic syndrome following bone marrow transplantation: report of two cases
1Department of Haematology and Medical Oncology, Peter MacCallum Cancer Institute, Melbourne, Australia.
Bone Marrow Transplantation
|February 1, 1994
Abstract:
We report two cases of secondary myelodysplastic syndrome (SMDS) which followed successful treatment of a primary malignancy with high-dose chemotherapy supported by reinfusion of autologous stem cells. The SMDS was diagnosed 24 months and 40 months, respectively, following autografting. Both patients lived for 7 months after the diagnosis of SMDS. Our cases support the view that there is an increased risk of SMDS/acute leukemia following autologous marrow transplantation.