Statistics of RNA melting kinetics
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M Tacker1, W Fontana, P F Stadler
1Institut für Theoretische Chemie, Universität Wien, Austria.
European Biophysics Journal : EBJ
|January 1, 1994
Abstract:
We present and study the behavior of a simple kinetic model for the melting of RNA secondary structures, given that those structures are known. The model is then used as a map that assigns structure dependent overall rate constants of melting (or refolding) to a sequence. This induces a "landscape" of reaction rates, or activation energies, over the space of sequences with fixed length. We study the distribution and the correlation structure of these activation energies.