Electrophysiological properties of the hyperthyroid rat heart

We have studied the effects of in vivo administration of different T3 doses to thyroidectomized rats on electrophysiological properties, measured in vitro, of papillary muscle fibers. The treatment with increasing T3 doses was associated with a significant reduction of the action potential duration up to a dose as large as 25 micrograms/100 g body weight every second day. The treatment with larger doses of T3 tended to restore the values of the action potential duration present in animals treated with physiological doses (5 micrograms/100 g body weight every second day). Action potential duration is frequency dependent. As the stimulation rate was increased from 1 to 5 Hz, this duration increased in all groups. However the difference between the rat groups remained significant. The cardiac frequency measured in unanaesthetized rats increased as the T3 doses. Furthermore the intrinsic frequency showed a similar increase, indicating a direct effect of T3 on the pacemaker cells in all thyroid states. The mechanism of this action of the thyroid hormone is not, however clear.