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Recurrent malignant histiocytosis with cerebrospinal involvement--case report
Neurologia Medico-Chirurgica
|April 1, 1994
Summary
Malignant histiocytosis rarely affects the central nervous system. Magnetic resonance imaging aids in diagnosing this rare brain condition, with treatment including irradiation and chemotherapy leading to remission.
Area of Science:
- Neurology
- Oncology
- Radiology
Background:
- Malignant histiocytosis is a rare, aggressive disorder of proliferating histiocytes.
- Central nervous system (CNS) involvement in malignant histiocytosis is uncommon but serious.
Observation:
- A 61-year-old male presented with recurrent malignant histiocytosis affecting the brain, causing nausea and headache.
- Magnetic resonance (MR) imaging revealed cerebrospinal fluid (CSF) dissemination with characteristic signal intensities on T1 and T2-weighted images.
- CSF cytology confirmed the presence of atypical histiocytes.
Findings:
- MR imaging demonstrated characteristic findings of CSF dissemination, including specific signal alterations and enhancement patterns.
- CSF cytological examination identified atypical histiocytes, confirming CNS involvement.
Implications:
- MR imaging is a valuable tool for diagnosing meningeal dissemination of malignant histiocytosis.
- Combined treatment with brain and spine irradiation, along with intrathecal chemotherapy (methotrexate and prednisolone), achieved remission.
- Early diagnosis and multimodal treatment are crucial for managing CNS malignant histiocytosis.