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Related Experiment Videos

The divided dosage/low dosage concept using fenbendazole

J G Gaenssler, C A Wilkins, W M O'Donnovan

    Journal of the South African Veterinary Association
    |December 1, 1978
    PubMed
    Summary

    Fenbendazole administered in feed blocks effectively treated cattle and sheep. This novel delivery method matched or surpassed traditional fenbendazole suspensions for anthelmintic efficacy.

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    Area of Science:

    • Veterinary Medicine
    • Parasitology
    • Animal Health

    Background:

    • Fenbendazole is a widely used anthelmintic in livestock.
    • Traditional administration methods include single-dose suspensions.
    • Developing novel delivery systems can improve efficacy and reduce resistance.

    Purpose of the Study:

    • To evaluate the efficacy of fenbendazole administered via feed blocks in cattle and sheep.
    • To compare this novel delivery method with standard single-dose fenbendazole suspensions.
    • To assess the potential for reduced anthelmintic resistance with divided dosages.

    Main Methods:

    • Fenbendazole was incorporated into feed blocks for cattle and sheep.
    • Dosages were 5 mg/kg for sheep and 10 mg/kg for cattle, divided over 4-5 days.
    • Anthelmintic effects were evaluated using a modified non-parametric method.

    Main Results:

    • Fenbendazole in feed blocks demonstrated anthelmintic efficacy comparable to or exceeding standard single-dose suspensions.
    • Divided dosages over 4-5 days were effective in treating cattle and sheep.
    • The delivery method showed promise in maintaining therapeutic levels and potentially mitigating resistance.

    Conclusions:

    • Fenbendazole administered via feed blocks is an effective anthelmintic for cattle and sheep.
    • This method offers an alternative to conventional suspensions and may help manage anthelmintic resistance.
    • Further research into divided dosage regimens is warranted for optimal livestock parasite control.

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