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Related Experiment Videos

Dopamine-dependent diastolic dysfunction in moderate hypothermia

T Schröder1, J P Hering, C F Heidelmeyer

  • 1Abteilung Anaesthesiologische Forschung, Universität Göttingen, Germany.

Journal of Cardiovascular Pharmacology
|May 1, 1994
PubMed
Summary
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Dopamine (DA) impacts diastolic function differently in hypothermia, potentially causing adverse reactions like aftercontractions. Careful consideration of these effects is crucial for clinical hypothermia drug administration.

Area of Science:

  • Cardiology
  • Physiology
  • Pharmacology

Background:

  • Hypothermia significantly alters cardiovascular function.
  • The effects of vasoactive drugs like dopamine (DA) during hypothermia require further investigation.

Purpose of the Study:

  • To investigate the effects of dopamine on diastolic function in sheep under normothermic and hypothermic conditions.

Main Methods:

  • An experimental animal study was conducted on 6 sheep.
  • Dopamine was administered at five incremental infusion rates during normothermia and moderate hypothermia (29°C).
  • Left ventricular end-diastolic pressure (LVEDP), contraction, and relaxation velocities were measured.

Main Results:

  • Left ventricular end-diastolic pressure (LVEDP) increased during hypothermia compared to normothermia across all dopamine doses.

Related Experiment Videos

  • Contraction and relaxation velocities showed minimal changes in hypothermia but were markedly increased in normothermia.
  • Aftercontractions occurred during hypothermia, intensifying hemodynamic effects, and resolved at very high dopamine doses.

    • Conclusions:

    • Hypothermia may reduce active transport mechanisms regulating cytoplasmic calcium (Ca2+), leading to paradoxical reactions to dopamine.
    • The reduced inotropic effect of dopamine, risk of paradoxical reactions, and aftercontractions are critical considerations for clinical hypothermia drug use.