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[Hypophyseal dysfunction and chronic hemodialysis]

H Holzer, R Goebel, H Pogglitsch

    Acta Medica Austriaca
    |January 1, 1978
    PubMed
    Summary
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    Chronic hemodialysis patients often experience elevated serum prolactin and human growth hormone (HGH) levels, potentially due to chronic stress. This study found impaired prolactin response to TRH in patients with high basal prolactin.

    Area of Science:

    • Endocrinology
    • Nephrology

    Context:

    • Chronic hemodialysis is a life-sustaining treatment for end-stage renal disease.
    • Patients undergoing hemodialysis can experience various endocrine dysregulations.
    • Elevated pituitary hormone levels, including prolactin and human growth hormone (HGH), have been observed in this population.

    Purpose:

    • To investigate serum prolactin, HGH, and thyroid-stimulating hormone (TSH) levels in chronic hemodialysis patients.
    • To assess the prolactin secretory response to thyrotropin-releasing hormone (TRH) in this cohort.
    • To explore potential correlations between hormone levels, menstrual status, and chronic stress.

    Summary:

    • 65 chronic hemodialysis patients exhibited elevated mean serum prolactin (35.5 ng/ml) and HGH (4.2 ng/ml), with normal TSH.

    Related Experiment Videos

  • A blunted prolactin response to TRH was noted in patients with high baseline prolactin.
  • Women with amenorrhea had significantly higher prolactin levels compared to menstruating women.
  • Chronic stress is hypothesized as a contributing factor to elevated prolactin and HGH.

    • Impact:

    • Highlights potential endocrine disturbances in chronic hemodialysis patients.
    • Suggests chronic stress as a possible etiological factor for hyperprolactinemia and elevated HGH in this group.
    • Informs clinical monitoring and management of hormonal imbalances in patients with kidney disease.