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Updated: Aug 10, 2026
12:24
Murine Model of CD40-activation of B cells
Published on: March 5, 2010
Low level CD20 expression on T cell malignancies
M J Warzynski1, D M Graham, R A Axtell
1West Michigan Flow Cytometry Service, Ferguson-Blodgett Hospital, Grand Rapids, MI 49503.
Cytometry
|June 15, 1994
Summary
Low antibody binding capacity (ABC) CD20 expression was found on T-acute lymphoblastic leukemia (T-ALL) cells. This finding helps differentiate T-cell malignancies from normal T cells and aids in monitoring disease recurrence.
Area of Science:
- Immunology
- Hematology
- Oncology
Background:
- CD20 is typically a B lineage restricted antigen.
- Recent studies have detected low antibody binding capacity (ABC) CD20 on a subset of normal T lymphocytes.
Observation:
- This study reports low ABC CD20 expression in three cases of T-acute lymphoblastic leukemia (T-ALL).
- Immunophenotypic analysis revealed a pure population of malignant T cells expressing CD7 and low ABC CD20.
- Other B lymphocyte associated antigens were negative.
Findings:
- Three cases of T-ALL exhibited low ABC CD20 expression (95%, 87%, 79% of malignant cells).
- This contrasts with the bright CD20 expression typically seen on normal B lymphocytes.
- Eleven other T-lymphocytic malignancies tested were CD20 negative.
Implications:
- Low ABC CD20 expression can serve as a unique immunophenotypic marker for T-cell neoplasia.
- This marker aids in distinguishing T-cell malignancies from normal or reactive T cells.
- The presence of low ABC CD20 may facilitate monitoring for residual or recurrent disease in T-ALL patients.
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