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Prostate-specific antigen in urine

J Breul1, U Pickl, R Hartung

  • 1Department of Urology, Klinikum rechts der Isar, Technische Universität München, FRG.

European Urology
|January 1, 1994
PubMed
Summary
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Urinary prostate-specific antigen (PSA) levels may help detect local recurrence after prostatectomy, even when serum PSA is undetectable. This urine test shows promise for post-prostatectomy follow-up.

Area of Science:

  • Urology
  • Oncology
  • Biochemistry

Background:

  • Prostate-specific antigen (PSA) is a key biomarker for prostate cancer.
  • Urinary PSA measurement is less common than serum PSA testing.
  • Understanding extraprostatic PSA sources is important for accurate interpretation.

Purpose of the Study:

  • To investigate urinary PSA concentrations in various patient groups.
  • To evaluate the utility of urinary PSA in detecting local recurrence after radical prostatectomy (RP).

Main Methods:

  • Collected mid-stream urine samples from 213 patients.
  • Included males with benign prostatic hypertrophy (BPH), localized prostate cancer, post-RP status, and other urological conditions, plus females.
  • Measured PSA levels using the Hybritech Tandem E method.

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Main Results:

  • Urinary PSA was detected in 38% of females and in men post-RP, likely from periurethral glands.
  • Urinary PSA levels did not differ significantly between BPH, organ-confined cancer, and other diagnoses.
  • Elevated urinary PSA was observed in some men with local recurrence post-RP, even with undetectable serum PSA.

Conclusions:

  • Urinary PSA detection in females and post-RP males suggests extraprostatic sources.
  • Urinary PSA levels are not consistently different across BPH, localized cancer, or other urological conditions.
  • Urinary PSA may serve as a valuable tool for monitoring local recurrence in patients after prostatectomy.