Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

On the origin of the genetic code

H Kuhn1, J Waser

  • 1Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany.

FEBS Letters
|October 3, 1994
PubMed
Summary
This summary is machine-generated.

This study postulates stages in the evolution of the genetic code, proposing an RNA-based translation system that links amino acids into peptides based on nucleotide sequences.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural basis for the positional specificity of lipoxygenases.

Prostaglandins & other lipid mediators·2000
Same author

Determinants of umbilical cord arterial 8-iso-prostaglandin F2alpha concentrations.

BJOG : an international journal of obstetrics and gynaecology·2000
Same author

A sensitive gas chromatography-mass spectrometry assay reveals increased levels of monohydroxyeicosatetraenoic acid isomers in human plasma after extracorporeal photoimmunotherapy and under in vitro ultraviolet A exposure.

The Journal of investigative dermatology·2000
Same author

[Transcoronary ablation of septal hypertrophy (TASH): a 5-year experience].

Zeitschrift fur Kardiologie·2000
Same author

Bacterial and nonbacterial expression of wild-type and mutant human phospholipid hydroperoxide glutathione peroxidase and purification of the mutant enzyme in the milligram scale.

Protein expression and purification·2000
Same author

Multilocular inoculation tuberculosis of the skin after stay in Africa: detection of mycobacterial DNA using polymerase chain reaction.

The British journal of dermatology·2000

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Origin of Life Studies

Background:

  • The genetic code's origin remains a fundamental question in molecular biology.
  • Understanding the transition from an RNA world to amino acid-based translation is crucial.

Purpose of the Study:

  • To postulate a series of logical stages in the evolution of the genetic code.
  • To propose a model for early translation machinery linking RNA and amino acids.

Main Methods:

  • Postulation of evolutionary stages based on a proposed translation model.
  • Description of an RNA-based system with hairpin molecules carrying amino acids.
  • Model of amino acid linkage facilitated by proximity on an RNA assembler strand.

Main Results:

Related Experiment Videos

  • A step-by-step evolutionary pathway for the genetic code is presented.
  • A "picket-fence" model of RNA-amino acid interaction is described.
  • Amino acid incorporation order is linked to availability and chemical properties.

Conclusions:

  • The proposed model offers a plausible mechanism for the origin of the genetic code.
  • Early translation likely involved RNA structures facilitating amino acid polymerization.
  • The genetic code's evolution was influenced by environmental availability and chemical constraints.