[Sodium valproate--current status of pharmacological research]
Related Experiment Video
Updated: Sep 21, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
1Department of Neurology, Institute of Psychiatry, London, England.
Abstract:
Valproic acid has a wider antiepileptic spectrum than any other antiepileptic drug (AED) in clinical use. Valproate administration causes many neurochemical and neurophysiological alterations, including increased GABA levels, modified GABA turnover and release, decreased gamma-hydroxybutyrate synthesis and release, increased serotonin and dopamine release, decreased aspartate levels, reduction of repetitive firing of neurons, and possibly a reduction in calcium (T) currents; however, none of these effects have consistently and unequivocally been linked to the antiepileptic action of valproate.
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