Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic analyses of cell-matrix interactions in development

R O Hynes1

  • 1Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.

Current Opinion in Genetics & Development
|August 1, 1994
PubMed
Summary

Extracellular matrix molecules and integrins are crucial for development. Gene mutations in mice reveal complex interactions between these components, impacting biological processes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

Leukemia·2017
Same author

Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.

Oncogene·2016
Same author

Cellular and subcellular localization of LETS protein in the nervous system.

Brain research·2011
Same author

Cell-matrix adhesion in vascular development.

Journal of thrombosis and haemostasis : JTH·2007
Same author

Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2007
Same author

Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.

Journal of thrombosis and haemostasis : JTH·2006

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cell Biology

Background:

  • The extracellular matrix (ECM) and cell surface receptors play vital roles in embryonic development.
  • In vitro studies and expression patterns suggest significant functions for ECM components and their receptors.

Purpose of the Study:

  • To investigate the in vivo functions of ECM molecules and integrins using targeted mutagenesis.
  • To elucidate the complexities of ECM-ligand and receptor-ligand interactions during development.

Main Methods:

  • Application of targeted mutagenesis techniques in mouse models.
  • Generation of 'knockout' mutations for specific matrix molecules and integrins.

Main Results:

  • Mutations affecting ECM molecules and integrins demonstrated complex developmental phenotypes.

Related Experiment Videos

  • Observed complexities arise from the interplay of multiple ECM receptors and their ligands.

    • Conclusions:

    • In vivo studies using gene knockout models are essential for understanding ECM and integrin functions.
    • The developmental roles of the extracellular matrix and integrins are intricate, involving multiple interacting components.