[Immunomorphological study of human tumors using the monoclonal antibody RMZh-1]

Monoclonal antibodies (MAB) were obtained against the antigens isolated from the fraction of external plasmatic membranes of human breast cancer (RMZh-I). 170 epithelial and non-epithelial primary and metastatic human tumours of various localization were studied by an immunoperoxidase method using the above antibodies. Positive reactivity with RMZh-I was observed in the epithelial tumors of mammary gland, uterus, ovaries, thyroid, lung, gastrointestinal tract, kidney. Mab did not react with hematopoietic and sarcomatous tumours. The parameters of the immunoperoxidase reaction were identical at both histologic and cytologic levels. MAB RMZh-I may be used as an epithelial marker for differential diagnosis of carcinoma metastases and lymphoproliferative disease.