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Benign glandular peripheral nerve sheath tumor. A case report
Y Oda1, H Hashimoto, M Tsuneyoshi
1Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Pathology, Research and Practice
|May 1, 1994
Summary
This study reports a rare case of a benign glandular peripheral nerve sheath tumor, a neoplasm typically found to be malignant. The benign tumor exhibited neurofibroma-like spindle cells and glandular elements with neuroendocrine differentiation.
Area of Science:
- Neuropathology
- Oncology
- Histology
Background:
- Glandular peripheral nerve sheath tumors (GPNSTs) are rare nerve sheath neoplasms.
- Most reported GPNSTs exhibit malignant characteristics.
- These tumors feature focally occurring glands with divergent differentiation.
Observation:
- A case of a benign GPNST in a 43-year-old woman is presented.
- Histologically, the tumor comprised spindle cells with neurofibroma-like features and glandular components.
- No mitotic figures were observed in the spindle cell areas.
Findings:
- Spindle cells showed positive S-100 protein expression.
- Glandular lining epithelium was positive for cytokeratins (CAM 5.2, AE1/AE3, PKK1) and EMA.
- Immunoreactivity for CEA, chromogranin, somatostatin, and Leu-7 supported neuroendocrine differentiation of the epithelial component.
Implications:
- This case expands the spectrum of GPNSTs to include benign variants.
- The findings suggest potential neuroendocrine differentiation within the schwannian component of GPNSTs.
- Further research may clarify the pathogenesis and clinical behavior of benign GPNSTs.