Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Viruses and schizophrenia

R L O'Reilly1

  • 1St Thomas Psychiatric Hospital, Ontario, Canada.

The Australian and New Zealand Journal of Psychiatry
|June 1, 1994
PubMed
Summary
This summary is machine-generated.

For over 70 years, a viral cause for schizophrenia has been explored. Recent evidence, including epidemiological data and sophisticated techniques, supports complex viral hypotheses for schizophrenia pathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia.

Clinical and translational medicine·2017
Same author

Integration of DNA sequence and DNA methylation changes in monozygotic twin pairs discordant for schizophrenia.

Schizophrenia research·2015
Same author

Benzodiazepines and Confusion in Medically Ill Alcoholics: Balancimg safety against toxicity.

Canadian family physician Medecin de famille canadien·2010
Same author

Copy number variation showers in schizophrenia: an emerging hypothesis.

Molecular psychiatry·2009
Same author

Most important lesson from Starson ignored in article.

Health law in Canada·2007
Same author

Is mandatory outpatient treatment effective?

Canadian journal of community mental health = Revue canadienne de sante mentale communautaire·2006
Same journal

Letter to the Editor regarding 'Middle childhood profiles of social-emotional competencies and difficulties differentiate risk of health service presentations with adolescent mental disorders'.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Diagnostic complexity and comorbidity: Implications for identification, outcomes, health care and involuntary treatment.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Defining and measuring psychosocial disability in Australia: Assessment of national surveys and administrative datasets.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Academic performance in children of mothers with perinatal depressive disorder.

The Australian and New Zealand journal of psychiatry·2026
Same journal

The Multisensory Hallucinations Schedule to assess hallucinations across multiple sensory modalities in psychosis: A pilot validation study.

The Australian and New Zealand journal of psychiatry·2026
Same journal

Student wellbeing supports in Australian and New Zealand medical schools: A post-guidance snapshot from a 14-institution survey.

The Australian and New Zealand journal of psychiatry·2026
See all related articles

Area of Science:

  • Neuroscience
  • Virology
  • Psychiatry

Background:

  • The viral hypothesis for schizophrenia pathogenesis has been considered for over 70 years.
  • Previous attempts to identify a specific causative virus have been unsuccessful.
  • Recent evidence has revitalized interest in the link between viral infections and schizophrenia.

Purpose of the Study:

  • To review the current state of research on viral hypotheses for schizophrenia.
  • To highlight recent epidemiological and molecular findings supporting a viral link.
  • To introduce complex viral etiological models currently under investigation.

Main Methods:

  • Review of epidemiological studies (e.g., birth seasonality, prenatal exposures).
  • Examination of advances in virology and molecular techniques.

Related Experiment Videos

  • Discussion of emerging complex viral hypotheses (neurodevelopmental disruption, autoimmunity, retroviral integration).

    • Main Results:

    • Epidemiological data show an excess of winter births in schizophrenia patients.
    • Evidence suggests prenatal exposure to viruses like influenza may increase schizophrenia risk.
    • Sophisticated techniques enable testing of complex viral mechanisms.

    Conclusions:

    • Complex viral hypotheses, including neurodevelopmental disruption and autoimmunity, are gaining traction.
    • These advanced hypotheses are now amenable to experimental testing.
    • Further research is needed to elucidate the role of viruses in schizophrenia etiology.