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Benign prostatic hyperplasia: it is a premalignant lesion?

D Grignon1, W Sakr

  • 1Department of Pathology, Harper Hospital, Detroit, MI 48201.

In Vivo (Athens, Greece)
|May 1, 1994
PubMed
Summary

Benign prostatic hyperplasia (BPH) and prostate cancer, common in aging men, may be linked. Atypical adenomatous hyperplasia (AAH) in the transition zone might connect these prostate conditions, requiring further biological study.

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Benign prostatic hyperplasia (BPH) and prostate cancer are prevalent in aging men.
  • Epidemiological studies on the association between BPH and prostate cancer have yielded conflicting results.
  • Recent research indicates some prostate cancers originate in the transition zone, where BPH also occurs.

Purpose of the Study:

  • To explore the potential link between benign prostatic hyperplasia (BPH) and prostate cancer.
  • To investigate the role of atypical adenomatous hyperplasia (AAH) as a possible precursor lesion connecting BPH and prostate cancer.

Main Methods:

  • Review of prior epidemiological and morphological studies.
  • Identification of atypical adenomatous hyperplasia (AAH) as a potential morphologic link.
  • Highlighting the need for future biological investigations.

Main Results:

  • Conflicting data exists regarding the association between BPH and prostate cancer.
  • A subset of prostate cancers arises in the transition zone, the same region affected by BPH.
  • Atypical adenomatous hyperplasia (AAH) is described as a potential morphologic bridge between BPH and prostate cancer.

Conclusions:

  • The transition zone of the prostate gland is implicated in both BPH and a subset of prostate cancers.
  • Atypical adenomatous hyperplasia (AAH) represents a potential precursor lesion requiring further biological study.
  • Biological investigation of AAH is essential to elucidate the relationship between BPH and prostate cancer.

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