Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neonatal alloimmune thrombocytopenia: current considerations

A B Glassman1, W J Shieh

  • 1Vanderbilt University Medical Center, Nashville, TN 37232.

Annals of Clinical and Laboratory Science
|September 1, 1994
PubMed
Summary

Mothers can develop antibodies against fetal platelet antigens, causing neonatal alloimmune thrombocytopenia (NAT). Early detection and treatment, including platelet infusions, are crucial for affected newborns.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of environmental factors on whole plant assimilate partitioning and associated gene expression.

Journal of experimental botany·2011
Same author

A man with chest pain and glomerulonephritis.

Lancet (London, England)·2005
Same author

Nipah virus infection, an emerging paramyxoviral zoonosis.

Springer seminars in immunopathology·2002
Same author

Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States.

Emerging infectious diseases·2001
Same author

Reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2001
Same author

Fatal encephalitis and myocarditis in young domestic geese (Anser anser domesticus) caused by West Nile virus.

Emerging infectious diseases·2001

Area of Science:

  • Immunology
  • Hematology
  • Perinatology

Background:

  • Maternal antibodies can target fetal platelet antigens, often due to prior transfusions or feto-maternal hemorrhage.
  • These sensitizing antigens are typically epitopes on platelet glycoproteins (GPs) involved in hemostasis.

Observation:

  • Neonatal alloimmune thrombocytopenia (NAT) occurs when a mother lacks a fetal platelet antigen and produces specific antibodies.
  • NAT incidence is 1/1,500 to 1/5,000 births, with potential for severe fetal bleeding and mortality.
  • NAT can manifest in the first pregnancy in about 50% of cases.

Findings:

  • Advances in obstetrics allow early fetal assessment via percutaneous umbilical blood sampling (PUBS).
  • Treatment options include cordocentesis with infusion of maternal or compatible platelets.
  • Identifying specific platelet antibodies remains a challenge for routine clinical labs due to reagent limitations.

Implications:

  • Accurate antibody identification is critical for effective NAT management.
  • Prenatal diagnosis and intervention can mitigate severe fetal complications.
  • Further development of diagnostic reagents is needed for improved clinical laboratory performance.

Related Experiment Videos