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Increased protein tyrosine-phosphorylation in primary T-cells transduced with Tax1 of human T-cell leukemia virus
1Virology Division, National Cancer Center Research Institute, Tokyo, Japan.
FEBS Letters
|January 16, 1995
Abstract:
Protein tyrosine-phosphorylation in primary human T-cells transduced with Tax1 of Human T-cell leukemia virus type I was investigated. In comparison with control T-cells, the level of protein tyrosine-phosphorylation after stimulation with anti-CD3 antibody increased significantly in Tax1-transduced T-cells. This enhancement in tyrosine-phosphorylation possibly accounted for the augmented proliferation response of these cells, which has been reported previously [J. Virol. 67 (1993) 1211-1217].