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Strategies for mapping and imitating viral B-cell epitopes

J Cason1

  • 1Richard Dimbleby Laboratory for Cancer Virology, Rayne Institute, St Thomas' Hospital, London, UK.

Journal of Virological Methods
|September 1, 1994
PubMed

Identification of viral B-cell epitopes is of importance in the selection of peptides for inclusion into subunit vaccines, the development of virus-specific serological tests and understanding the interaction of antibodies with viruses at a molecular level. B-cell epitopes can often be determined unequivocally by X-ray analyses of antibody-antigen complexes. This technique is, however, time-consuming and alternative strategies have now been developed for identifying epitopes. This article provides an overview of approaches which are currently available for mapping and imitating B-cell epitopes.

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