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Cleaved L-selectin concentrations in meningeal leukaemia
A Stucki1, A S Cordey, N Monai
1Division of Haematology, University of Lausanne, Switzerland.
Lancet (London, England)
|February 4, 1995
Summary
Measuring shed L-selectin in cerebrospinal fluid (CSF) can help detect central nervous system involvement in acute leukaemia. Elevated CSF sL-selectin indicates meningeal leukaemia, aiding diagnosis and monitoring therapy effectiveness.
Area of Science:
- Hematology
- Neuro-oncology
- Biochemistry
Background:
- Central nervous system involvement in acute leukaemia presents diagnostic challenges.
- Accurate detection of leukaemic infiltration in cerebrospinal fluid (CSF) is crucial for effective treatment.
- The shed form of L-selectin (sL-selectin) is often elevated in acute leukaemia.
Purpose of the Study:
- To evaluate the utility of CSF sL-selectin as a marker for meningeal leukaemia.
- To determine if CSF sL-selectin levels correlate with leukaemic infiltration in the central nervous system.
Main Methods:
- Assayed CSF sL-selectin levels in patients with acute leukaemia and meningeal involvement.
- Compared CSF sL-selectin levels with those in patients without meningeal involvement and healthy controls.
- Conducted serial measurements of CSF sL-selectin in patients undergoing treatment.
Main Results:
- CSF sL-selectin was significantly higher in patients with sL-selectin+ meningeal leukaemia compared to controls and patients without meningeal involvement.
- Elevated CSF sL-selectin levels were observed in patients with therapy-resistant meningeal leukaemia.
- Normal CSF sL-selectin concentrations correlated with remission in treated patients.
Conclusions:
- CSF sL-selectin is a sensitive marker for detecting meningeal involvement in sL-selectin+ acute leukaemia.
- This marker may aid in the diagnosis and monitoring of leukaemic meningitis.
- Assessing CSF sL-selectin offers a valuable tool for managing CNS leukaemia.