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Recurrent acute pancreatitis induced by isoniazid
1Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin.
Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|October 1, 1994
Summary
Isoniazid treatment for tuberculosis can cause acute pancreatitis in patients undergoing hemodialysis. Stopping isoniazid resolved the pancreatitis, and alternative tuberculosis drugs were safely used.
Area of Science:
- Nephrology
- Gastroenterology
- Infectious Diseases
Background:
- Pulmonary tuberculosis treatment requires careful drug selection, especially in patients with comorbidities.
- Hemodialysis patients present unique challenges due to altered drug metabolism and excretion.
Observation:
- A 31-year-old male on hemodialysis experienced recurrent acute pancreatitis during tuberculosis treatment.
- Pancreatitis symptoms resolved upon discontinuation of isoniazid.
- Recurrence of pancreatitis was noted upon isoniazid reintroduction.
Findings:
- Isoniazid is a potential causative agent for drug-induced acute pancreatitis in hemodialysis patients.
- Rifampicin and pyrazinamide were safely administered for a full year, indicating their suitability as alternatives.
Implications:
- Clinicians should consider isoniazid as a potential cause of pancreatitis in patients on hemodialysis.
- Alternative anti-tuberculosis regimens are effective and safe for patients experiencing isoniazid-induced pancreatitis.