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Prostate-specific antigen obtained under optimal conditions determines extracapsular adenocarcinoma of the prostate
J T Ehreth1, J I Miller, R B McBeath
1Department of Pathology, University of Arizona Health Sciences Center, Tucson Medical Center.
Objective:
To assess the relationship of prostate-specific antigen (PSA) obtained under optimal conditions with the presence or absence of organ-confined prostate cancer following radical prostatectomy.
Patients And Methods:
The medical records of 300 consecutive patients who underwent radical retropubic prostatectomy were retrospectively reviewed. Ninety-three patients were excluded who had a pre-operative PSA level potentially altered by various factors (prostate infection, manipulation or instrumentation).
Results:
A pre-operative PSA value < 4 ng/mL accurately predicted pathologically confined disease in 42 of 51 patients (82%) which contrasted with extracapsular disease in 74 of 84 patients (88%) who had a PSA value > 10 ng/mL. One of the 53 patients with a PSA > 15 ng/mL had organ-confined disease at surgery.
Conclusion:
These data demonstrate that optimal serum PSA values correlate well with pathological stage.
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