Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial cell activation in patients with systemic vasculitis

J R Bradley1, C M Lockwood, S Thiru

  • 1Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, UK.

QJM : Monthly Journal of the Association of Physicians
|December 1, 1994
PubMed
Summary

Endothelial cells in systemic vasculitis show activation markers like ICAM-1 and VVCAM-1, mirroring in vitro responses and influencing inflammatory reactions. This study highlights their role in cutaneous inflammation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advanced hybrid nanocomposites for infrastructure renewal: enhanced shear and flexural performance in load-bearing applications.

Scientific reports·2026
Same author

An analytical characterization study on biofuel obtained from pyrolysis of Madhuca longifolia residues.

Scientific reports·2024
Same author

Depression, anxiety and PTSD symptoms before and during the COVID-19 pandemic in the UK.

Psychological medicine·2022
Same author

Mitochondria-targeted antioxidant MitoQ ameliorates ischaemia-reperfusion injury in kidney transplantation models.

The British journal of surgery·2021
Same author

Neutralising antibodies in Spike mediated SARS-CoV-2 adaptation.

medRxiv : the preprint server for health sciences·2021
Same author

Repeat duplex ultrasound scanning in suspected Deep Vein Thrombosis (DVT): putting the onus back on the referring clinician.

Acute medicine·2016

Area of Science:

  • Immunology
  • Cell Biology
  • Dermatology

Background:

  • Vascular endothelial cells (VECs) alter function and morphology when exposed to stimuli like cytokines, promoting inflammation.
  • Endothelial cell activation is a key process in inflammatory reactions.

Purpose of the Study:

  • To investigate endothelial cell activation in vivo within skin biopsies of patients with systemic vasculitis.
  • To correlate the expression of adhesion molecules with inflammatory cytokines and cellular infiltrates.

Main Methods:

  • Analysis of 20 skin biopsies from 18 patients with systemic vasculitis.
  • Assessment of endothelial cell morphology and expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leucocyte adhesion molecule-1 (ELAM-1).

Related Experiment Videos

  • Correlation of adhesion molecule expression with inflammatory cytokines and infiltrating immune cells (mononuclear cells and neutrophils).

    • Main Results:

    • Swollen endothelial cells expressing increased ICAM-1 and VCAM-1 were observed at sites of cutaneous inflammation.
    • Neutrophil infiltration was associated with the expression of ELAM-1 (present in 15/20 biopsies).
    • ELAM-1 and VCAM-1 expression correlated with the presence of inflammatory cytokines.

    Conclusions:

    • In vivo endothelial cell activation in systemic vasculitis resembles in vitro findings.
    • Endothelial activation plays a significant role in determining the characteristics of the inflammatory response in vasculitis.