[Use of Diprivan in allergic patient]

Propofol may be indicated in patients with a history of allergy provided some precautions are taken. At present, the only contra-indication for propofol are patients with a known allergy to muscle relaxants. Any anaphylactoid reaction has to be systematically reported (e.g. to the Drug Safety Department of Zeneca Pharma) and the patient tested according to the standard protocol, in order to further disclose the underlying mechanisms and evaluate the risk factors. Periodical analysis of notifications of adverse reactions will facilitate regular epidemiological studies and the update of the information on the drug for the anaesthetic community.