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Vascularisation of ocular coralline hydroxyapatite implants
C Menzel1, F Grünwald, M Busin
1Department of Nuclear Medicine, University of Bonn, Germany.
European Journal of Nuclear Medicine
|December 1, 1994
Summary
Vascularisation of coralline hydroxyapatite implants is crucial for ocular prosthesis. Technetium-99m DPD SPET confirms early and complete vascularisation by 4 months post-implantation.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Medical Imaging
Background:
- Coralline hydroxyapatite implants are used to replace enucleated bulbs in ocular prosthetics.
- Successful integration requires adequate vascularisation for motility peg implantation.
Purpose of the Study:
- To evaluate the rate and completion time of vascularisation in coralline hydroxyapatite implants.
- To assess the utility of Technetium-99m diphosphopropanedicarboxylic acid (DPD) single-photon emission tomography (SPET) in monitoring this process.
Main Methods:
- Twenty-four patients received coralline hydroxyapatite implants.
- Vascularisation was assessed using 99mTc-DPD SPET at 10 days, 2 months, and 4 months post-implantation.
- Visual scoring of vascularisation from 0 (none) to + (complete) was performed.
Main Results:
- No tracer accumulation was observed at the 10-day follow-up.
- Progressive vascularisation was evident over time.
- Complete vascularisation was achieved in 18 out of 19 patients by the 4-month mark.
Conclusions:
- Ocular coralline hydroxyapatite implant vascularisation is an early process.
- Full vascularisation is typically completed within 4 months.
- 99mTc-DPD SPET is recommended for confirming vascularisation at 4 months.