Related Experiment Videos
Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation
C J Elson1, R N Barker, S J Thompson
1University of Bristol Dept of Pathology and Microbiology, UK.
Immunology Today
|February 1, 1995
Abstract:
The factors that may cause antigen-presenting cells to alter the pattern of protein processing and presentation to autoreactive T cells, and thereby stimulate autoimmune disease, are currently under debate. In this article, Chris Elson and colleagues suggest that cytokines associated with T helper 1 (Th1) cells alter the processing of proteins and that this effect can be counteracted by Th2-associated cytokines.