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Effect of neurotensin and substance P on adrenal cortex regeneration
W Zieleniewski1, J Zieleniewski
1Department of Clinical Endocrinology, University School of Medicine, Lodz, Poland.
Abstract:
The influence of neurotensin (NT) and substance P (SP) on the early stage of adrenal regeneration was investigated. Neurotensin (5 and 50 micrograms/kg) and SP (10 and 100 micrograms/kg) were given to rats subjected to adrenal enucleation combined with contralateral adrenalectomy. The mitotic index was employed to assess cell growth, and plasma corticosterone was determined by a radioimmunological assay. The animals were killed 4 and 8 days after operation. Neurotensin did not evoke any significant changes either in the proliferation ratio or corticosterone production of regenerating adrenal cortex. However, it was found that SP (100 micrograms/kg) stimulated both the proliferation and steroidogenesis on the eighth day after operation.
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