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Related Experiment Videos

Keratin expression in cutaneous lichen planus

J K Schofield1, D De Berker, A Milligan

  • 1Department of Experimental Dermatology, London Hospital Medical College, UK.

Histopathology
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

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This study reveals altered keratin expression in lichen planus, showing changes similar to wound healing. These keratin abnormalities may stem from inflammatory responses within the skin.

Area of Science:

  • Dermatology
  • Cell Biology
  • Molecular Biology

Background:

  • Keratinocytes normally express specific keratins, with altered profiles seen in hyperproliferative conditions like psoriasis and wound healing.
  • Cutaneous lichen planus is an inflammatory skin disorder with poorly understood differentiation abnormalities.

Purpose of the Study:

  • To analyze keratin expression in cutaneous lichen planus to identify abnormalities in keratinocyte differentiation.
  • To compare the keratin profile of lichen planus to other skin conditions.

Main Methods:

  • Utilized a panel of monoclonal antibodies to study keratin expression.
  • Analyzed 28 samples from 20 patients with cutaneous lichen planus.

Main Results:

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  • Squamous differentiation remained unaffected, with normal expression of keratins K1 and K10.
  • Abnormalities included the basal cell marker LH8 extending into suprabasal layers.
  • Keratin K17, typically in adnexal structures, was expressed in basal and suprabasal layers of affected epidermis.
  • Keratins K6 and K16, usually suprabasal in hyperproliferation, were found both basally and suprabasally.

    • Conclusions:

    • The keratin profile in lichen planus resembles that of wound healing.
    • Changes in keratin K17 expression suggest hyperproliferative responses.
    • Epidermal keratin expression alterations are likely due to cytokine and inflammatory mediator production from the lymphocytic infiltrate.