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Lipopolysaccharide toxicity-regulating proteins in bacteremia
A H Froon1, M A Dentener, J W Greve
1Department of Surgery, University Hospital Maastricht, University of Limburg, Netherlands.
The Journal of Infectious Diseases
|May 1, 1995
Summary
Bactericidal/permeability-increasing protein (BPI) and LPS-binding protein (LBP) levels increase before bacteremia detection. The BPI/neutrophil ratio indicates neutrophil activation and predicts sepsis syndrome and death in patients with bacteremia.
Area of Science:
- Infectious Diseases
- Immunology
- Biochemistry
Background:
- Lipopolysaccharide (LPS) toxicity is modulated by proteins like BPI and LBP.
- BPI neutralizes LPS effects, while LBP enhances them.
- Understanding these interactions is crucial for managing bacterial infections.
Purpose of the Study:
- To investigate plasma levels of BPI and LBP in patients with Gram-negative or Gram-positive bacteremia.
- To assess the association of BPI and LBP levels, and the BPI/neutrophil ratio, with sepsis syndrome and patient outcomes.
- To determine the utility of these markers in monitoring infectious diseases.
Main Methods:
- Plasma BPI and LBP levels were measured in 64 patients with bacteremia (36 Gram-negative, 28 Gram-positive).
- The BPI/neutrophil ratio was calculated as an indicator of neutrophil activation.
- Statistical analyses were performed to correlate marker levels with sepsis syndrome and survival.
Main Results:
- Elevated BPI and LBP levels were observed before the clinical detection of bacteremia.
- The BPI/neutrophil ratio was significantly higher in patients with sepsis syndrome and in non-survivors.
- High LBP peak levels were also associated with sepsis syndrome.
- No significant differences in BPI or LBP levels were found between Gram-negative and Gram-positive bacteremia groups.
Conclusions:
- The BPI/neutrophil ratio serves as a valuable indicator of neutrophil activation in bacteremic patients.
- This ratio may aid in predicting sepsis syndrome and mortality.
- BPI and LBP levels could be useful biomarkers for monitoring infectious disease progression.