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[Lichen planus and hepatitis C]

H Benchikhi1, F Nejjam, S Habibeddine

  • 1Service de Dermatologie, CHU Ibn Rochd, Casablanca, Maroc.

Annales De Dermatologie Et De Venereologie
|January 1, 1994
PubMed
Summary
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Lichen planus and hepatitis C are increasingly linked. These three new cases suggest a non-fortuitous association, possibly due to hepatitis C virus triggering an immune response.

Area of Science:

  • Immunology
  • Hepatology
  • Dermatology

Background:

  • Increasing reports suggest a link between lichen planus and hepatitis C virus (HCV) infection.
  • Understanding this association is crucial for patient diagnosis and management.

Observation:

  • Three new cases (2 male, 1 female; ages 46-63) presented with oral lichen planus.
  • Two cases showed oral lichen planus during HCV recovery; one case had lichen planus preceding HCV diagnosis.
  • Hepatitis C was confirmed using second-generation ELISA.

Findings:

  • The observed cases provide further evidence for a non-fortuitous association between oral lichen planus and hepatitis C.
  • The temporal relationship varied, with lichen planus appearing before or after HCV diagnosis.

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Implications:

  • Hepatitis C virus may trigger an immune response leading to both chronic hepatitis and lichen planus.
  • This association warrants further investigation into the immunological mechanisms involved.
  • Clinicians should consider screening for hepatitis C in patients with oral lichen planus.