Effect of the antiallergic drug disodium cromoglycate and various derivatives on alkaline phosphatase
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E Ochoa de Aspuru1, A M Lourdes Zatón
1Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Basque Country, Vitoria-Gasteiz, Spain.
Journal of Enzyme Inhibition
|January 1, 1994
Abstract:
Disodium cromoglycate (DSCG) inhibits alkaline phosphatase in a non-competitive manner, the enzyme undergoing a conformational change which is attenuated by the presence of calcium ions. The structurally related pyranone and benzoic acid are weak inhibitors of the enzyme and produce a similar conformational change. Coumarin does not induce any conformational change in the enzyme suggesting that the 4-oxo group in DSCG may be essential for its effect.