Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD44 is expressed throughout pre-implantation human embryo development

S Campbell1, H R Swann, J D Aplin

  • 1Department of Obstetrics and Gynaecology, University Hospital of South Manchester, UK.

Human Reproduction (Oxford, England)
|February 1, 1995
PubMed
Summary

The cell surface glycoprotein CD44 is present in human oocytes, early embryos, and placental stroma cells. Its presence is down-regulated on the embryonic surface after implantation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A pilot study to investigate the effect of insemination on secretory cell activity post-ovulation in the isthmus of the equine oviduct.

Journal of equine veterinary science·2026
Same author

Evidence of glycan mosaicism in the equine oviduct.

Journal of equine veterinary science·2025
Same author

Investigating the role of CD44 and hyaluronate in embryo-epithelial interaction using an in vitro model.

Molecular human reproduction·2019
Same author

Studies of the dynamics of nuclear clustering in human syncytiotrophoblast.

Reproduction (Cambridge, England)·2016
Same author

Quality assurance and its impact on ovarian visualization rates in the multicenter United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2015
Same author

Tracking nutrient transfer at the human maternofetal interface from 4 weeks to term.

Placenta·2015

Area of Science:

  • Reproductive biology
  • Developmental biology
  • Cell biology

Background:

  • The cell surface glycoprotein CD44 is found in various embryonic and adult tissues.
  • CD44 plays roles in cell adhesion, migration, and proliferation.

Purpose of the Study:

  • To investigate the presence and distribution of CD44 in human reproductive tissues and early embryonic development.
  • To determine CD44 expression patterns during preimplantation and early postimplantation stages.

Main Methods:

  • Indirect immunofluorescence was used to detect CD44.
  • Analysis included human oocytes, cumulus cells, early embryos, pre-hatched blastocysts, and placental tissues.

Main Results:

  • CD44 was detected on human oocytes, cumulus cells, early embryos, and pre-hatched blastocysts.

Related Experiment Videos

  • CD44 was present on placental stroma cells (8-11 weeks) but absent on trophoblast cells.
  • Expression of CD44 was observed throughout preimplantation development.

    • Conclusions:

    • CD44 is present during human preimplantation development.
    • CD44 expression is down-regulated on the embryonic surface following implantation.
    • These findings highlight CD44's potential role in early human development and implantation.