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Relationship between lower urinary tract abnormalities and disease-related parameters in multiple sclerosis
E L Koldewijn1, O R Hommes, W A Lemmens
1Department of Urology, University Hospital Nijmegen, The Netherlands.
The Journal of Urology
|July 1, 1995
Summary
Lower urinary tract symptoms are common in multiple sclerosis (MS) patients. Abnormalities correlate with disease duration and disability, but severe upper tract issues are rare.
Area of Science:
- Neurology
- Urology
Background:
- Multiple sclerosis (MS) frequently impacts the lower urinary tract.
- The connection between MS-related urinary dysfunction and disease parameters is not well understood.
Purpose of the Study:
- To investigate the relationship between lower urinary tract abnormalities and multiple sclerosis disease parameters.
- To assess the prevalence of urodynamic abnormalities in MS patients.
Main Methods:
- 212 patients with multiple sclerosis were evaluated using a standard urological and neurological protocol.
- Urodynamic assessments were performed to identify lower urinary tract dysfunction.
- Disease-related parameters including duration, disability, cerebrospinal fluid myelin basic protein, and neurophysiological tests were analyzed.
Main Results:
- 52% of patients reported micturition complaints, and 64% showed urodynamic abnormalities.
- Detrusor hyperactivity and hypoactivity correlated with disease duration, disability status, CSF myelin basic protein levels, and neurophysiological findings.
- No correlation was found between detrusor hypersensibility/hyposensibility and disease parameters.
- Severe upper urinary tract abnormalities were rare, noted in only one patient.
Conclusions:
- Lower urinary tract abnormalities are prevalent in multiple sclerosis patients, irrespective of disease state.
- Specific urodynamic findings in MS are associated with disease severity and duration.
- While common, severe upper urinary tract complications are infrequent in multiple sclerosis.