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c-met proto-oncogene expression in benign and malignant human prostate tissues
L L Pisters1, P Troncoso, H E Zhau
1Department of Urology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
The Journal of Urology
|July 1, 1995
Summary
Prostate cancer cells frequently express the c-met receptor, the target of hepatocyte growth factor/scatter factor (HGF/SF). This finding suggests c-met may play a role in prostate cancer progression and metastasis.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- Hepatocyte growth factor/scatter factor (HGF/SF) is a mitogen for prostatic epithelial cells.
- The HGF/SF receptor is encoded by the c-met proto-oncogene.
- Prostate cancer progression may involve responses to growth factors in the tumor microenvironment.
Purpose of the Study:
- To assess the presence and localization of c-met protein in benign and malignant prostate tissues.
- To correlate c-met protein expression with prostate cancer stage, grade, and androgen sensitivity.
Main Methods:
- Immunohistochemical techniques were used to detect c-met protein.
- Benign and malignant prostate tissues, including metastases, were analyzed.
- Expression levels were correlated with clinical parameters.
Main Results:
- c-met protein was detected in the basal layer of normal prostate glands but not luminal cells.
- c-met was found in 91% of high-grade prostatic intraepithelial neoplasia (PIN) foci.
- 84% of primary prostate cancers and 100% of lymph node and bone marrow metastases showed c-met staining.
- c-met expression correlated significantly with higher tumor grade (p < 0.001).
Conclusions:
- c-met protein is frequently expressed in prostatic intraepithelial neoplasia and higher-grade prostate cancers.
- The frequent detection of c-met in advanced prostate cancer suggests a potential role in tumor progression and metastasis.
- Further research is warranted to elucidate the biological significance of c-met in prostate cancer.