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A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice
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The effect of colchicine and vinblastine on bleomycin-induced lung fibrosis in rats

A Ledwozyw1

  • 1Department of Pathophysiology, Veterinary Faculty of Agricultural Academy, Lublin, Poland.

Acta Physiologica Hungarica
|January 1, 1994
PubMed

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Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...