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Do autoantibodies to IgE play a role in IgE-mediated events?
F Shakib1, S J Smith, D I Pritchard
1Department of Immunology, Medical School, Queen's Medical Centre, Nottingham, UK.
Abstract:
Elevated blood levels of IgG anti-IgE are detectable in individuals exhibiting enhanced IgE production, namely those with allergic conditions and helminthic parasite infections. The fact that there are epitope-specific subpopulations of autoanti-IgE suggests that this autoantibody could potentially have multiple effects in immunological events involving IgE.
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