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A maternal factor affecting mouse blastocyst formation

J P Renard1, P Baldacci, V Richoux-Duranthon

  • 1Biologie du Développement, INRA, Jouy en Josas, France.

Development (Cambridge, England)
|April 1, 1994
PubMed
Summary
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A maternal factor in DDK mouse oocytes prevents blastocyst formation by interacting with the paternal genome. This RNA-based factor, active in early embryos, demonstrates novel maternal control over mouse development.

Area of Science:

  • Developmental Biology
  • Genomics
  • Epigenetics

Background:

  • Normal mouse embryo development necessitates both maternal and paternal genomes due to differential genomic imprinting.
  • Early interactions between egg cytoplasm and pronuclei can program the embryonic genome and influence parental contribution.
  • Evidence suggests maternal factors can modulate embryonic genome programming during preimplantation stages.

Purpose of the Study:

  • To investigate the role of maternal factors in early mouse embryonic development.
  • To identify and characterize a specific maternal factor present in DDK mouse oocytes that affects blastocyst formation.

Main Methods:

  • Utilized the mouse mutant strain DDK for oocyte collection.
  • Assayed for the presence and activity of a maternal factor in ovulated oocytes and preimplantation embryos.

Related Experiment Videos

  • Investigated the interaction of this maternal factor with the paternal genome.

    • Main Results:

    • A maternal factor present in DDK mouse oocytes was identified.
    • This factor prevents the formation of the blastocyst.
    • The factor, an RNA, interacts with the paternal genome and remains active in preimplantation embryos.

    Conclusions:

    • This study provides the first direct evidence of maternal control over blastocyst formation in mice.
    • A maternally derived RNA factor in DDK oocytes actively inhibits embryonic development by interacting with the paternal genome.
    • This finding highlights the critical role of maternal factors in regulating early embryonic programming and development.