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Temporal (circadian) and functional relationship between prostate-specific antigen and testosterone in healthy men
H Mermall1, R B Sothern, E L Kanabrocki
1Pathology and Laboratory Medicine, Hines Veterans Affairs Hospital, Illinois, USA.
Urology
|July 1, 1995
Summary
Serum prostate-specific antigen (PSA) and testosterone show distinct circadian rhythms in healthy men, indicating different physiological states throughout the day. This temporal relationship may influence chronopharmacologic considerations for prostate treatments.
Area of Science:
- Endocrinology
- Urology
- Chronobiology
Background:
- Prostate-specific antigen (PSA) and testosterone levels can fluctuate.
- Understanding these fluctuations is crucial for accurate diagnosis and treatment.
Purpose of the Study:
- To investigate the 24-hour circadian relationship between serum PSA and total testosterone in healthy men.
- To assess the impact of age on these hormonal levels.
Main Methods:
- Collected blood samples every 3 hours for 24 hours from 11 healthy men (ages 46-72).
- Monitored PSA weekly for 6 weeks in 16 additional healthy men.
- Analyzed circadian rhythms using cosine analysis and correlated hormone levels with age using linear regression.
Main Results:
- Mean PSA positively correlated with age, while testosterone negatively correlated with age.
- Both PSA and testosterone exhibited significant circadian rhythms.
- PSA showed a mean circadian range of change of 28% and testosterone of 53%.
Conclusions:
- The distinct circadian rhythms of PSA and testosterone suggest varying physiological states over 24 hours.
- This temporal relationship has potential chronopharmacologic implications for prostate-related treatments.
- Within-day PSA variation has minimal impact on clinical classification using single specimens.