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Epithelially derived endothelin and nitric oxide in asthma
P H Howarth1, A E Redington, D R Springall
1Immunopharmacology Group, University Medicine Southampton General Hospital, UK.
International Archives of Allergy and Immunology
|May 1, 1995
Summary
Asthma involves increased airway endothelin (ET) and nitric oxide synthase (iNOS). This peptide and enzyme balance may influence airway tone and thickening, potentially impacting asthma control.
Area of Science:
- Pulmonary Medicine
- Molecular Biology
- Immunology
Background:
- Asthma is characterized by airway inflammation and hyperresponsiveness.
- Endothelin (ET) and inducible nitric oxide synthase (iNOS) are implicated in airway патофизиология.
Purpose of the Study:
- To investigate the expression and potential roles of ET and iNOS in asthma.
- To explore the relationship between ET, nitric oxide (NO), and airway function in asthma.
Main Methods:
- Immunohistochemical staining of endobronchial biopsies.
- Measurement of ET concentrations in bronchoalveolar lavage fluid.
- Analysis of exhaled nitric oxide (NO) levels.
Main Results:
- Increased expression of ET and iNOS in the airway epithelium of asthma patients.
- Elevated ET levels in bronchoalveolar lavage fluid correlate with resting airflow obstruction.
- Elevated NO in exhaled air is observed in asthma.
Conclusions:
- The balance between ET and nitric oxide synthase (NOS) may regulate resting bronchomotor tone in asthma.
- ET promotes airway wall thickening and hyperresponsiveness by stimulating fibroblast activity and collagen deposition.
- Targeting ET and NOS pathways could be a strategy for asthma control.