Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glomerular function of lead-exposed workers

K S Chia1, J Jeyaratnam, C Tan

  • 1Department of Community, Occupational and Family Medicine, National University Hospital, Singapore.

Toxicology Letters
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Analysis of posterior uterus approach combined with vascular occlusion in placenta percreta].

Zhonghua fu chan ke za zhi·2026
Same author

[Liver function and distribution of liver fibrosis in older adults aged 65 years and above in 18 longevity areas in China].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026
Same author

Effect of Blood-Air Contact on Blood-Based Perfusates for Ex Vivo Lung Perfusion Using an In Vitro Approach<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Impact of daratumumab refractoriness on clinical outcomes following CAR T-cell therapy for relapsed refractory multiple myeloma.

Blood cancer journal·2025
Same author

[Progress of researches on mechanisms underlying immune escape of <i>Plasmodium</i>].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2025
Same author

[Distribution characteristics and long-term change trend of body mass index in Chinese older adults aged 65 years and above].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025
Same journal

LEF1 regulated CTHRC1 promotes silica-induced pulmonary fibrosis through CD44-dependent signaling.

Toxicology letters·2026
Same journal

hERG channel blockade and additive interactions of magnolol and honokiol from Magnolia species.

Toxicology letters·2026
Same journal

Evaluation of dose-dependent hematotoxic effects of celastrol on human blood cells in vitro.

Toxicology letters·2026
Same journal

Environmental pharmaceutical and antibiotic mixtures: An exposomics-guided framework for mechanistic toxicology.

Toxicology letters·2026
Same journal

Size- and morphology-dependent cytotoxicity of metal-organic frameworks: Deciphering the structure-toxicity relationship.

Toxicology letters·2026
Same journal

Steroidogenesis suppression in H295R cells by 1,3-disubstituted ureas: A potential off-target effect of some sEH inhibitors.

Toxicology letters·2026
See all related articles

Long-term lead exposure in workers may harm kidney function, indicated by elevated serum beta 2-microglobulin. Even below 700 µg/L, blood lead levels can negatively impact glomerular filtration.

Area of Science:

  • Occupational Health
  • Nephrology
  • Toxicology

Background:

  • Chronic renal diseases are linked to increased mortality in lead-exposed workers.
  • Previous studies using early markers failed to detect renal changes in lead-exposed individuals.

Purpose of the Study:

  • To assess glomerular function in lead-exposed workers.
  • To evaluate the relationship between glomerular function markers and lead exposure indices.

Main Methods:

  • Investigated 137 lead-exposed workers and 153 controls.
  • Derived exposure indices: time-integrated blood lead (PbBint), PbB above critical values (PbB400, PbB500, PbB600).
  • Analyzed serum beta 2-microglobulin (S beta 2m), alpha 1-microglobulin (S alpha 1m), urinary albumin (UA1b), and creatinine clearance (CrCl4h).

Related Experiment Videos

Main Results:

  • PbBint best predicted variations in S beta 2m, S alpha 1m, and UA1b.
  • Lead-exposed workers showed significantly higher S beta 2m abnormalities.
  • High PbBint correlated with abnormal S beta 2m and decreased CrCl4h, suggesting potential nephropathy even below 700 µg/L.

Conclusions:

  • Elevated S beta 2m and UA1b are associated with prolonged high blood lead levels.
  • Decreased CrCl4h may be linked to sustained high blood lead exposure.
  • Current lead exposure thresholds may not fully prevent lead nephropathy.