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Canine distemper virus-specific antibodies in multiple sclerosis
C Rohowsky-Kochan1, P C Dowling, S D Cook
1Department of Neurosciences, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA.
Neurology
|August 1, 1995
Summary
Canine distemper virus may cause multiple sclerosis (MS) in genetically susceptible individuals. Research shows a significant association between high canine distemper virus antibody titers and MS, suggesting a potential zoonotic cause.
Area of Science:
- Neuroimmunology
- Virology
- Infectious Diseases
Background:
- Multiple sclerosis (MS) is thought to be triggered by an infectious agent causing an autoimmune reaction against brain antigens in genetically susceptible individuals.
- Evidence for an infectious cause of MS is largely indirect.
- Canine distemper virus (CDV), a measles-like virus in dogs, is a proposed zoonotic agent implicated in MS causation.
Purpose of the Study:
- To investigate the potential role of canine distemper virus (CDV) in the etiology of multiple sclerosis (MS).
- To determine if humans can be infected with CDV and if CDV antibodies are associated with MS.
Main Methods:
- Serological analysis to detect antibodies against canine distemper virus.
- Statistical association studies correlating antibody titers with MS diagnosis.
Main Results:
- Evidence suggests that humans can be infected with the neurotropic canine distemper virus.
- A significantly high titer of canine distemper virus antibodies was found to be associated with multiple sclerosis.
Conclusions:
- Canine distemper virus is a potential etiological agent in some cases of multiple sclerosis.
- Identification of CDV as a causative agent could advance understanding of MS pathogenesis and inform public health strategies, including vaccination.