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[Multiple sclerosis]

H Nyland1, K M Myhr

  • 1Nevrologisk avdeling Haukeland Sykehus, Bergen.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|June 30, 1995
PubMed
Summary

Multiple sclerosis (MS) is a chronic central nervous system inflammatory disease. Treatments can impact MRI findings and relapse frequency but do not reverse established neurological dysfunction.

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Multiple sclerosis (Houndmills, Basingstoke, England)·2015

Area of Science:

  • Neurology
  • Immunology

Context:

  • Multiple sclerosis (MS) is a chronic inflammatory central nervous system disease impacting young and middle-aged adults.
  • Disease course and prognosis vary significantly among patients, with relapsing-remitting, secondary progressive, and primary progressive forms.
  • Magnetic resonance imaging (MRI) is crucial for diagnosing subclinical disease activity.

Purpose:

  • To review the pathophysiology, clinical presentation, and diagnostic approaches to multiple sclerosis.
  • To discuss current treatment strategies and their impact on disease markers and progression.

Summary:

  • MS involves demyelination mediated by activated microglial cells and T helper cells, likely triggered by viral infections and autoimmune responses to myelin antigens.
  • While treatments like corticosteroids and interferons influence MRI activity and relapse rates, their effect on the overall disease course remains less convincing.
  • No current therapy can reverse long-standing neurological deficits in multiple sclerosis.

Impact:

  • Highlights the importance of MRI in monitoring MS activity and treatment response.
  • Underscores the limitations of current therapies in halting disease progression or reversing existing neurological damage.
  • Provides a concise overview for clinicians and researchers on the current understanding and management of multiple sclerosis.

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