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Molecular mechanisms underlying functional T-cell unresponsiveness

D L Mueller1, M K Jenkins

  • 1University of Minnesota Medical School, Department of Medicine, Minneapolis 55455, USA.

Evidence from tissue culture experiments and in vivo studies indicates that certain forms of antigen presentation render T cells unresponsive to subsequent antigenic stimulation. Great progress has been made recently in understanding the induction, maintenance, and in vivo relevance of this unresponsive state, called clonal anergy.

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