Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biologic differences between early- and late-onset Alzheimer disease

R D Terry1

  • 1Department of Neurosciences, University of California, San Diego, La Jolla 92093-0624, USA.

Alzheimer Disease and Associated Disorders
|January 1, 1995
PubMed
Summary

Normal aging causes neuron shrinkage and synapse loss in the brain. Differences in aging susceptibility across the central nervous system may explain variations in early- versus late-onset disease presentations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Presentation of the gold headed cane award to harry m. Zimmerman: 1982.

The American journal of pathology·2009
Same author

Tangles precede plaques but don't cause them.

Neurobiology of aging·2004
Same author

Life span and synapses: will there be a primary senile dementia?

Neurobiology of aging·2001
Same author

An honorable compromise regarding amyloid in Alzheimer disease.

Annals of neurology·2001
Same author

Commentary. Copernicus revisited: amyloid beta in alzheimer disease.

Neurobiology of aging·2001
Same author

Cell death or synaptic loss in Alzheimer disease.

Journal of neuropathology and experimental neurology·2001

Area of Science:

  • Neuroscience
  • Aging Research
  • Pathology

Background:

  • Normal aging is associated with structural changes in the central nervous system, including neuronal shrinkage and synaptic loss.
  • The neocortex is particularly susceptible to age-related alterations.
  • Different regions of the central nervous system exhibit varying degrees of vulnerability to aging processes.

Purpose of the Study:

  • To investigate the differential susceptibility of central nervous system regions to age-related changes.
  • To explore how premorbid aging affects the presentation of neurological diseases.
  • To differentiate between age-related changes and distinct disease pathogenesis.

Main Methods:

  • Comparative analysis of aging effects across different central nervous system regions.

Related Experiment Videos

  • Histological examination of neuronal size and synaptic density.
  • Longitudinal studies tracking age-related changes and disease onset.

    • Main Results:

    • Significant shrinkage of large neurons and loss of synapses were observed in the neocortex with normal aging.
    • Variations in the extent of age-related changes were noted across different parts of the central nervous system.
    • Premorbid age-related alterations were identified as a potential factor influencing disease presentation.

    Conclusions:

    • Age-related neuronal and synaptic changes in the neocortex are a normal aging process.
    • Differential susceptibility to aging across the central nervous system can influence the apparent differences between early- and late-onset diseases.
    • Observed variations in disease presentation may be attributed to premorbid aging rather than fundamentally different disease mechanisms.