[Effects of polyionic compounds on the metabolism of the swine cell line IB-RS-2]

The effects of polyons DEAE-dextran and dextran sulfate on IB-RS-2 cells were studied. DEAE-dextran (5 microgram/ml) inhibited cell growth and decreased the synthesis of proteins and RNA, while the synthesis of DNA remained essentially unchanged. Those effects depend on time of cell exposition to this compound. Dextran-sulfate (5 microgram/ml) increased cell growth, but inhibited protein synthesis and on a lesser extent the synthesis of RNA; those effects were seen 48 hours after the addition of Dextran-sulfate to the maintenance medium. The synthesis of DNA remained essentially unchanged.