Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Donor factors

N J Feduska, J M Cecka

    Clinical Transplants
    |January 1, 1994
    PubMed
    Summary
    This summary is machine-generated.

    Kidney transplant outcomes vary by donor factors. Male donors and trauma cases show better graft survival, while older donors and Black donors have poorer outcomes. Kidney type and blood type also influence success rates.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Paul I. Terasaki, PhD, 1929-2016.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
    Same author

    HLA high-resolution typing for sensitized patients: a solution in search of a problem?

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
    Same author

    Kidney paired donation in the presence of donor-specific antibodies.

    Kidney international·2013
    Same author

    Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatches.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010
    Same author

    Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failure.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010
    Same author

    HLA matching for organ transplantation…why not?

    International journal of immunogenetics·2010
    Same journal

    Clinical Relevance of Donor-Specific IgM Antibodies in HLA Incompatible Renal Transplantation: A Retrospective Single-Center Study.

    Clinical transplants·2017
    Same journal

    Influenza Immunization and the Generation of Anti-HLA and Anti-MICA Antibodies in Patients with Renal Failure and in Kidney Transplant Recipients.

    Clinical transplants·2017
    Same journal

    From Accurate Assessment of Anti-HLA Antibody MFI to Complement-Binding Assays.

    Clinical transplants·2017
    Same journal

    Post-transplant Desensitization for Deceased Donor Kidney Transplant Recipients: A Single Center Experience.

    Clinical transplants·2017
    Same journal

    Acute Rejection in 6-Antigen HLA-Matched Kidney Transplant Recipients: Risk Factors and Outcomes from the Wisconsin Allograft Recipient Database (WisARD).

    Clinical transplants·2017
    Same journal

    C1q Donor-Specific Antibody Associates with Post-transplant Biopsy Findings in Highly- Sensitized Kidney Transplant Recipients.

    Clinical transplants·2017
    See all related articles

    Area of Science:

    • Nephrology
    • Transplantation Immunology
    • Public Health

    Background:

    • Kidney transplantation is a vital treatment for end-stage renal disease.
    • Understanding factors influencing graft survival is crucial for optimizing patient outcomes.
    • Donor characteristics significantly impact the long-term success of kidney transplants.

    Purpose of the Study:

    • To analyze the impact of various donor characteristics on kidney graft survival rates.
    • To identify specific donor factors associated with improved or diminished transplant success.
    • To provide data-driven insights for donor selection and transplant strategies.

    Main Methods:

    • Retrospective analysis of kidney transplant data.
    • Comparison of graft survival rates based on donor laterality (left vs. right).

    Related Experiment Videos

  • Evaluation of graft survival across different donor demographics (sex, race, age, blood type) and causes of death (trauma vs. nontrauma).

    • Main Results:

    • Left kidneys showed a slightly higher 1-year survival rate, but left and right kidneys were comparable long-term. En bloc transplants had lower survival.
    • Male donor kidneys had superior graft survival compared to female donor kidneys.
    • Kidneys from Black donors had lower survival rates and shorter half-lives than White, Hispanic, or Asian donors. Type O donors had better survival than AB, A, or B.
    • Pediatric and older donor kidneys (over 60) exhibited significantly lower graft survival rates. Trauma donors had higher survival rates.

    Conclusions:

    • Donor sex, race, age, and cause of death are critical determinants of kidney transplant graft survival.
    • Blood type O donors are associated with better long-term graft survival.
    • Further research into addressing disparities in Black donor kidney outcomes is warranted.
    • Optimizing donor selection criteria based on these factors can improve kidney transplant success.