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[Gliomatosis cerebri. Ante-mortem diagnosis]
E Rivas1, J Guzmán, E Mora-La Cruz
1Departamento de Patología, Hospital General del Sur, Maracaibo, Venezuela.
Investigacion Clinica
|September 1, 1995
Summary
Gliomatosis Cerebri, a rare central nervous system (CNS) tumor, involves widespread glial cell proliferation. This case highlights a rare ante-mortem diagnosis of Gliomatosis Cerebri.
Area of Science:
- Neuro-oncology
- Neuropathology
Background:
- Gliomatosis Cerebri is a rare, diffuse neoplastic proliferation of glial cells within the central nervous system (CNS).
- It is characterized by infiltrative growth rather than destructive lesions, often leading to late diagnosis, typically at autopsy.
Observation:
- A 46-year-old woman presented with a 15-year history of focal seizures, recent behavioral changes, vertigo, incontinence, and falls.
- CNS imaging demonstrated extensive white matter involvement in both cerebral hemispheres.
Findings:
- Stereotactic guided biopsy revealed a moderately cellular astrocytic neoplasm.
- This case represents a rare instance of Gliomatosis Cerebri diagnosed ante-mortem.
Implications:
- This case underscores the importance of considering Gliomatosis Cerebri in the differential diagnosis of diffuse CNS white matter abnormalities.
- Ante-mortem diagnosis allows for potential earlier therapeutic interventions and improved patient management strategies.